Ohio State University (OSU) released ENS CFD study results and published an article entitled “Computational Fluid Dynamics and Trigeminal Sensory Examinations of Empty Nose Syndrome Patients”. Brief summary of the article:

This prospective case control study investigated the pathogenesis of ENS, examining changes in nasal aerodynamics and nasal trigeminal sensory function among a small group of ENS patients. The results indicated that a combination of factors may contribute to the development of ENS including: paradoxically distorted nasal aerodynamics, impaired sensorineural sensitivity, and potential predisposing conditions.

Decreased nasal resistance and flowrates were observed in the ENS patients using computational fluid dynamic (CFD) simulations. The results showed significantly increased airway cross-sectional area post-surgery, especially in the inferior region, which paradoxically resulted in significant flow rate reduction. Paradoxically, inferior turbinate (IT) reduction did not draw more airflow to the airway surrounding the IT; rather, there was a reduction of airflow intensity surrounding the IT for all ENS patients.

 Altered airflow patterns were also observed. Pre-surgical nasal airflow patterns were evenly distributed throughout the inferior and lateral regions of the nasal airway, while post-surgical nasal airflow patterns showed a reduced airflow intensity surrounding the inferior turbinate. In addition, new airflow patterns were directed toward the middle meatal region in a narrow jet.

ENS patients were found to have significantly lowered menthol lateralization detection thresholds (LDT) in an assessment of nasal trigeminal sensitivity compared to healthy controls. Since nasal trigeminal sensitivity potentially mediates the perception of airflow, this finding confirmed nasal neurosensory impairment among the ENS patients. 

An interesting finding of the study demonstrated that symptoms related to ENS did not necessarily result from the most radical resection of turbinate tissue

Hyperlink to the full article: https://www.ncbi.nlm.nih.gov/pubmed/28278356

Important: the study continues and patients still get enrolled – don’t miss your chance to participate! It will help you understand your ENS case better and also will contribute to better understanding of ENS and its qualitative research. More details can be found at: